A NOVEL SUBUNIT VACCINE BASED ON FIBER1/2 KNOB DOMAIN PROVIDES FULL PROTECTION AGAINST FOWL ADENOVIRUS SEROTYPE 4 AND INDUCES STRONGER IMMUNE RESPONSES THAN A FIBER2 SUBUNIT VACCINE

ABSTRACT: Outbreaks of hepatitis-hydropericardium syndrome (HHS) caused by fowl adenovirus serotype 4 (FAdV-4) have resulted Party in huge economic losses to the poultry industry in China since 2015.However, commercially available vaccines against the FAdV-4 infection remain scarce.In our study, subunit vaccine candidates derived from the bacterial

Background: Poor recruitment is one key reason for premature closure of randomised controlled trials.The Melatonin for Anxiety prior to General Anaesthesia In Children (MAGIC) trial was a multicentre randomised controlled trial of melatonin vs midazolam in the premedication of anxious children, before surgery.The trial ran between 2019 and 2022, cl

In this paper, Neuro-Fuzzy Friction Estimation Models (NFFEM) are developed to estimate the joint friction coefficients in a Triple Link Rotary Inverted Adaptive Dinnerware Pendulum (TLRIP) system and compared with an Adaptive Friction Estimation Models (AFEM).The different versions of AFEMs and NFFEMs are generated based on each of the following f

The offshoring of more advanced activities is increasing and a debate about the limits of offshoring has emerged.Companies are fine-slicing their value chains, and moving beyond the offshoring of peripheral and non-core activities to the offshoring of advanced and essential activities that are closer to their core (e.g.research, design and product